中文簡介

《毒理學機制與方法》是一份同行評審的期刊，每季出版一期，其目標是雙重的。首先，該雜志包含了關于外來化學物質引起毒性組織損傷機制的原始研究。感興趣的化學物質包括工業化合物、環境污染物、危險廢物、藥物、殺蟲劑和化學戰劑。該雜志的范圍從分子和細胞的作用機制，到考慮建立監管政策的機制證據。其次，該雜志涉及開發、驗證和應用新的和現有的實驗室方法、技術和設備。討論了多種研究方法，包括:用標準種和替代種進行體內研究;體外研究和替代方法;分子、生化和細胞技術;藥物動力學和藥效學;數學建模和計算機程序;法醫分析;風險評估;數據收集和分析。毒理學機制和方法為來自工業、政府和學術界的毒理學家、藥理學家和生物化學家等眾多專業人士提供了關于有毒物質測定、評價和檢測及其影響的最關鍵問題的全面報道。

　　英文簡介

Published quarterly, Toxicology Mechanisms and Methods is a peer-reviewed journal whose aim is twofold. Firstly, the journal contains original research on subjects dealing with the mechanisms by which foreign chemicals cause toxic tissue injury. Chemical substances of interest include industrial compounds, environmental pollutants, hazardous wastes, drugs, pesticides, and chemical warfare agents. The scope of the journal spans from molecular and cellular mechanisms of action to the consideration of mechanistic evidence in establishing regulatory policy. Secondly, the journal addresses aspects of the development, validation, and application of new and existing laboratory methods, techniques, and equipment. A variety of research methods are discussed, including: in vivo studies with standard and alternative species; in vitro studies and alternative methodologies; molecular, biochemical, and cellular techniques; pharmacokinetics and pharmacodynamics; mathematical modeling and computer programs; forensic analyses; risk assessment; data collection and analysis. Toxicology Mechanisms and Methods provides comprehensive coverage of the most critical issues in the determination, evaluation and testing of toxic substances and their effects for a wide variety of professionals, including toxicologists, pharmacologists, and biochemists from industry, government and academia.

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